Role of cyclic nucleotides in the proliferation of committed granulocyte-macrophage progenitor cells.

The proliferative response of murine hemopoietic pro genitor cells to the stimulatory actions of colony-stimulating factor can be antagonized by agents that elevate cyclic adenosine 3':5'-monophosphate and can be potentiated by agents associated with increases in cyclic guanosine 3':5'monophosphate. The granulocyte-macrophage progenitor cell is profoundly inhibited by the E-series prostaglandins, whereas its proliferative ability can be augmented by low concentrations of prostaglandin F._,«. The existence of differ ent receptors for prostaglandins E and F, determined with the prostaglandin antagonist, SC-19220, correlates with the differential effects of the two prostaglandin subclasses on colony-stimulating factor action. A role of cyclic adeno sine 3':5'-monophosphate in the mediation of prostaglan